Nieuws – LymphChip Consortium

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Nieuws

Wij zijn verheugd te kunnen aankondigen dat het LymphChip-project nu officieel van start is gegaan.

Paraxial mesoderm as a direct gateway to lymphatic endothelial cells

Paraxial mesoderm as a direct gateway to lymphatic endothelial cells

januari 16, 2025

Valeria Orlova and Tatiana Petrova have published a paper in Nature Cardiovascular Research in which the origins of mammalian lymphatic vessels have been studied. In conclusion, the centripetal model via the paraxial mesoderm lineage may offer a more promising approach for direct differentiation of LECS in vitro without the need to pass through an intermediate […]

Workshop Maskless Photolitography & Indentation

Workshop: Maskless Photolithography & Indentation

januari 28, 2025

Dear LymphChip members, On March 4 the hands-on Workshop: Maskless Photolithography & Indentation organized by Alvéole, Optics11 Life and LUMC will be held at Sylviusweg 62 in Leiden, The Netherlands. A QR code to register for this workshop is presented in the attached flyer and below. Costs are 200 Euro (academic), 230 Euro (industry).

Midterm Self-evaluation LymphChip

Midterm Self-evaluation LymphChip

november 25, 2024

Three NWA-ORC consortia: BioClock, LOSS and LymphChip met November 25 at the Lorentz Center in Leiden for a midterm self-evaluation to work towards societal impact. During the day best practices, challenges, needs and actions were discussed by young and senior researchers and by representatives from co-funding and cooperation partners.

Inaugural lecture Hans Bouwmeester LymphChip

Inaugural lecture Hans Bouwmeester LymphChip

november 22, 2024

On November 22, Hans Bouwmeester, PI in LymphChip presented his inaugural lecture entitled: “Is complexity always better? Connecting cells to systems in toxicology”. Within LymphChip, Hans Bouwmeester takes the lead in the development of an immunocompetent Intestine-on-chip model.

Young TPI workshop

Young TPI Impact Workshop October 31: Still some spots left

oktober 28, 2024

Early-career researchers: Please sign up for the Young TPI Impact Workshop on October 31st in Utrecht. A few in-person spots are still available. Sign up now and don’t miss out: https://lnkd.in/eQJP42KA In this hands-on workshop, we’ll dive into topics such as overcoming animal bias in publishing, transforming research into products and services, and communicating your findings […]

3rd Annual Meeting LymphChip

3rd Annual Meeting LymphChip

oktober 24, 2024

On October 21-22, the third Annual Meeting of LymphChip took place at the Leiden University Medical Center (LUMC), bringing together 35 participants from our academic and co-financing partners, as well as members of the Advisory Board. The event kicked off with research updates from all work packages, providing a comprehensive overview of the progress made […]

Theano Tsikari is invited to give talks and received a travel grant

Theano Tsikari is invited to give talks and received a travel grant

Theano Tsikari, PhD student within LymphChip at the Orlova lab at LUMC, has been selected to give a flash talk and has also received a travel grant for the EMBO workshop entitled “Building networks: engineering in vascular biology” which is held in Barcelona on May 6-8, 2024. In addition, she has been invited to give […]

LymphChip Summer School 2024

LymphChip Summer School 2024

Researchers of both LymphChip and SmartOoC academic partners are invited to attend the LymphChip Summer School 2024 which will feature workshops on career development, business development, academic writing and scientific illustrations. The deadline for registration is May 1, 2024. For more information, please contact Anne Leferink.

Kick-off Immuno-Gut (spin-off LymphChip Helpathon)

The kick-off meeting of Immuno-Gut took place on March 28, 2024 at the Mirai House home of the Department of Anatomy and Embryology of LUMC. This project is financed with a phase 1 Create2Solve grant from ZonMw and aims at the optimization and standardization of methods to produce serum and Matrigel free iPSC derived immune […]

Hans van der Aa, COO of PolyVation, gave a technology seminar in which he presented the capabilities of PolyVation and the various applications of their custom-made polymers. Depending on the need of the customer, the properties of the polymers can be tweaked to control for instance the physical and biological properties of the materials. Application areas of these polymers include medical devices, tissue engineering and drug delivery.
Within LymphChip, the PolyVation polymers are used for the biofabrication of biomimetic 3D microscaffolds for advanced skin and gut-on-chip models with integrated lymphatics and immune cells

Technology Seminar on custom-made specialty polymers

Hans van der Aa, COO of PolyVation, gave a technology seminar in which he presented the capabilities of PolyVation and the various applications of their custom-made polymers. Depending on the need of the customer, the properties of the polymers can be tweaked to control for instance the physical and biological properties of the materials. Application […]

Nikon Imaging Course

Nikon Imaging Course

On March 19 and 20, 2024 five PhD students attended an Organ-on-Chip imaging course designed to deepen their understanding of intricate 3D imaging and analysis techniques. This course was organized by the Nikon BioImaging Lab in Leiden. In preparation for this two-day course an online technical seminar was held in which the imaging possibilities were […]

Lifetime achievement award Sue Gibbs

Lifetime achievement award Sue Gibbs

december 12, 2023

Once every ten years the Willy van Heumen lifetime achievement award is presented to a researcher with a special track record in research to Replace, Reduce and Refine animal studies. On December 12, 2023 Sue Gibbs was awarded with this price for her scientific contribution to reduce the use of animals for experiments, to educate […]

Create2Solve grant

Create2Solve grant

december 6, 2023

In May 2023, LymphChip organized Helpathon #8 asking help to find animal-free alternatives for serum and Matrigel. As a direct result of this Helpathon, an application was submitted to the Create2Solve Phase 1 call of ZonMw to optimize and standardize methods to produce serum and Matrigel free iPSC derived immune competent intestine: Immuno-Gut. Immuno-Gut got […]

Monitoring organs-on-chip: a story by Massimo Mastrangeli

december 5, 2023

This year Massimo Mastrangeli was appointed as Associate Professor at TU Delft. In his research he exploits his knowledge on microelectronics to create a home for human cells outside the human body. With a combination of soft and hard materials an environment is created to host cells or tissues, the chip. Stimulation of these cells […]

2nd Annual Meeting LymphChip

2nd Annual Meeting LymphChip

november 1, 2023

On October 30-31 the second Annual Meeting of LymphChp was hosted by VUMC in Amsterdam. In total 39 members of LymphChip attended the program representing the academic partners, co-financing partners and the Advisory Board. The first day consisted of news updates on behalf of all the work packages. Most attendees joined for dinner that evening. […]

First research paper LymphChip published

First research paper LymphChip published

Ulgu Arslan, Christine Mummery, Valeria Orlova and co-authors have published the first research paper of LymphChip entitled “Vascularized hiPSC-derived 3D cardiac microtissue on chip”. The paper has been published in Stem Cell Reports and is publicly available. This paper was also featured on the cover of the July 11, 2023 issue. Please find the publication […]

Pratik Tawade is selected for the 72nd Lindau Nobel Laureate Meetings in Physiology and Medicine.

The KNAW has nominated Pratik Tawade as a young scientist to participate in the 72nd Lindau Nobel Laureate Meetings in Physiology and Medicine. This meeting will occur from 25-30 June 2023 in Lindau, Germany. Since its foundation in 1951, the Lindau Nobel Laureate Meetings have developed into a unique international scientific forum. The annual meetings […]

Helpathon LymphChip

Helpathon LymphChip

From May 22-24 LymphChip will organize a Helpathon in the O2 Building of VUmc. If you want to help Sue, Margot, Valeria, Jasper and Germaine finding animal-free alternatives for FCS and Matrigel please sign up via this link. All help, both negative and positive results are welcome. For more information please see here.

3rd prize for Theano Tsikaro of LymphChip at hDMT meeting

3rd prize for Theano Tsikari of LymphChip at hDMT meeting

november 25, 2022

The annual meeting of hDMT was held in Amersfoort and attracted may researchers from the organ-on-chip field. As part of the program a PhD student Spotlight competition was organized to give PhD students the opportunity to present their research with a short video.

3rd Technology Seminar on the generation of phenotypic assays

3rd Technology Seminar on the generation of phenotypic assays

november 8, 2022

Sei Hien Lim from AIM Biotech gave a seminar to illustrate the applications of their idenTx and organiX plates in the fields of oncology, immune-oncology, vascular biology and neurobiology.

Autumn Tour LymphChip

oktober 26, 2022

From September 20 till October 26, in total 18 PhD students, postdocs and technicians of the academic partners of LymphChip joined a tour consisting of site visits to all the academic labs.

Annual Meeting LymphChip

Annual Meeting LymphChip

oktober 20, 2022

On October 20-21 the Annual Meeting of LymphChip was hosted by VUMC in Amsterdam. In total 36 members of LymphChip participated representing the academic partners, co-financing partners and the Advisory Board. All the work packages presented their results and future plans.

2nd Technology Seminar on the use of Primo

2nd Technology Seminar on the use of Primo

Hélène Delobel from Alvéole presented a technology seminar on the use of Primo for photopatterning applications with many practical examples as published in the literature. Dhanesh Kasi from LUMC shared his experience with Primo further highlighting the advantage of the use of Primo to prototype chip designs and engineer microvascular networks.

Optics11 Naointender at LUMC

Optics11 Naointender at LUMC

We are thrilled with Chiaro Nanointender installed in our PRIMO (Alveolé) microfabrication lab at LUMC. We look forward to exploring the mechanical properties of engineered heart tissues and hydrogels as a part of the LymphChip project.

Screenshot Nostics voor Technol Seminar May 3 2022

1st Technology Seminar on Surface Enhanced Raman Spectroscopy

Vincent Laban, co-founder and CEO of Nostics partner of LymphChip presented a technology seminar on their Surface Enhanced Raman Spectroscopy technology. This Technology Seminar was the first in a series where the industrial partners of LymphChip present their technology to the members of LymphChip.

News item Bring in the Lymph

Bring in the lymph

Valeria Orlova (LUMC), Sue Gibbs (VUMC) and Carine van Schie (DBF) have been interviewed by NWO about the LymphChip project. For more information please read the full article at:

Kick-off Meeting LymphChip

Kick-off Meeting LymphChip

februari 21, 2022

February 15, 2022 The Kick-off Meeting was organized in Spatial Chat in view of COVID-19 restrictions. In total 44 members of LymphChip participated representing the academic partners, co-financing partners and the Advisory Board. Plenary sessions were held to present the aims of LymphChip, to learn about the expectations and contributions from co-financing partners and to […]

hDMT meeting

LymphChip project is presented during the annual hDMT Consortium meeting, November 12th, 2021

november 8, 2021

On November 12, 2021 Dr Valeria Orlova the project leader of LymphChip will present the LympChip consortium to the members of hDMT. She will highlight the objectives of the three research themes on technology development, on the generation of the hiPSC-derived tissue specific cells and on the integration to ultimately lead to functional organs on […]

PI meeting

LymphChip PI Meeting, October 25th, 2021

oktober 25, 2021

On October 25, 2021 the principal investigators of LymphChip gathered online to discuss amongst others the recruitment of PhD students and postdocs (we do have vacancies, please keep an eye on the vacancies page on our website) and the kick-off meeting that is scheduled for February 15, 2022.

Granting of application:

NWA-ORC grant for Organ-on-Chip models with integrated lymphatics

november 27, 2020

A 5 million Euro NWA-ORC grant was awarded to hDMT researchers to develop immunocompetent human Organ-on-Chip models with integrated lymph drainage for drug discovery and testing (LymphChip). The project is led by Valeria Orlova (coordinator) from Leiden University Medical Center (LUMC), Christine Mummery (LUMC) and Sue Gibbs (VUMC). The lymphatic system plays a crucial role […]

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Contact

lymphchip@lumc.nl

Project Manager:

Margot Beukers
Science Business Support

Project management for life sciences research projects including training and advice

https://sbsupport.nl

The LymphChip consortium is funded by the NWA-ORC programme of the Dutch Research Council
(NWO; project number 1292.19.019)