Paraxial mesoderm as a direct gateway to lymphatic endothelial cells

January 16, 2025

Valeria Orlova and Tatiana Petrova have published a paper in Nature Cardiovascular Research in which the origins of mammalian lymphatic vessels have been studied. In conclusion, the centripetal model via the paraxial mesoderm lineage may offer a more promising approach for direct differentiation of LECS in vitro without the need to pass through an intermediate venous lineage via the centrifugal model.

The link to the full publication is: https://rdcu.be/d5ovE

More news

Advancing Vascular Research: Successful hiPSC Workshop at LUMC

Vascular on Chip course with support from AIMBiotech

December 3, 2025

Advancing Vascular Research: Successful hiPSC Workshop at LUMC On December 1st and 2nd, Valeria Orlova’s team, along with the Leiden hiPSC Center and the Leiden OoC facility, successfully held their first workshop on hiPSC-based vascular in vitro modeling at LUMC. The course consisted of a combination of expert lectures and hands-on time in our training […]

Inaugural Lecture – Prof.dr. Andries van der Meer

October 2, 2025

On Thursday, October 2, 2025, Prof.dr. Andries van der Meer, Professor of Microphysiological Systems at the University of Twente, delivered his inaugural lecture titled “Orgaan-op-een-Chip” on the campus of the University of Twente. Prof. van der Meer is internationally recognized for his pioneering work in Organs-on-Chips, microengineered devices that mimic the structure and function of […]

Join the Conversation on Animal-Free Innovation

September 17, 2025

YTPI Conference 2025 – Connecting the Dots October 23–24, 2025 | Trippenhuis, Amsterdam How can we accelerate the transition to animal-free science and innovation? This October, the Young TPI invites researchers, educators, policymakers, and innovators to a two-day conference exploring the many facets of the animal-free transition — from cutting-edge technologies to policy, education, and social […]