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Author: LymphChip

LymphChip review paper on the interplay between lymph node extracellular matrix, fibroblasts and immune cells

Daphne Panocha and Reina Mebius have published a review in Trends in Immunology about the complex interplay between lymph node extracellular matrix, fibroblasts and immune cells. Understanding this interplay will help the development of a human physiological lymph node-on-chip which can mimic human adaptive immune responses. The link to the full publication is: Lymph node fibroblast-produced extracellular matrix shapes immune function: Trends in Immunology

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Successful Workshop on Maskless Photolithography & Nano-Indentation

On March 4th, the LUMC OoC Centre, Alvéole and Optics11 Life together organized a workshop focused on maskless photolithography and nano-indentation techniques. The day started with an introduction to the techniques and how to apply them to a range of research questions by experts from both companies and the LUMC. Following the introduction, the participants were divided into small groups to apply what they had learned directly: each group developed their own mini-research plan, learning how to work with the software packages necessary to develop a pattern for the hands-on...

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LymphChip cardiac microtissue paper among the top 10 cited papers in Stem Cell Reports

Stem Cell Reports has presented a list of the 10 highly cited publications published during 2023-2024. The publication of Ulgu Arslan on vascularized hiPSC-derived 3D cardiac microtissue on chip is one of these papers, please see the link below. Top-cited stem cell papers    We are pleased to present a selection of highly cited papers published during 2023-2024 in Stem Cell Reports that highlight the significant role it fulfills in advancing the field. Generation of anti-GD2 CAR macrophages from human pluripotent stem cells for cancer immunotherapies Zhang...

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Paraxial mesoderm as a direct gateway to lymphatic endothelial cells

Valeria Orlova and Tatiana Petrova have published a paper in Nature Cardiovascular Research in which the origins of mammalian lymphatic vessels have been studied. In conclusion, the centripetal model via the paraxial mesoderm lineage may offer a more promising approach for direct differentiation of LECS in vitro without the need to pass through an intermediate venous lineage via the centrifugal model. The link to the full publication is: https://rdcu.be/d5ovE

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Workshop: Maskless Photolithography & Indentation

Dear LymphChip members, On March 4 the hands-on Workshop: Maskless Photolithography & Indentation organized by Alvéole, Optics11 Life and LUMC will be held at Sylviusweg 62 in Leiden, The Netherlands. A QR code to register for this workshop is presented in the attached flyer and below. Costs are 200 Euro (academic), 230 Euro (industry). Download the flyer

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Midterm Self-evaluation LymphChip

Three NWA-ORC consortia: BioClock, LOSS and LymphChip met November 25 at the Lorentz Center in Leiden for a midterm self-evaluation to work towards societal impact. During the day best practices, challenges, needs and actions were discussed by young and senior researchers and by representatives from co-funding and cooperation partners.

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Inaugural lecture Hans Bouwmeester LymphChip

On November 22, Hans Bouwmeester, PI in LymphChip presented his inaugural lecture entitled: “Is complexity always better? Connecting cells to systems in toxicology”. Within LymphChip, Hans Bouwmeester takes the lead in the development of an immunocompetent Intestine-on-chip model.

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Young TPI Impact Workshop October 31: Still some spots left

Early-career researchers:Please sign up for the Young TPI Impact Workshop on October 31st in Utrecht. A few in-person spots are still available.Sign up now and don’t miss out: https://lnkd.in/eQJP42KA In this hands-on workshop, we’ll dive into topics such as overcoming animal bias in publishing, transforming research into products and services, and communicating your findings to any audience. Bonus: Pitch Training & Toekomstproef EventYou’ll also get professional pitch training and the chance to present your research to a live audience at Proefdiervrij’s Toekomstproef...

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3rd Annual Meeting LymphChip

On October 21-22, the third Annual Meeting of LymphChip took place at the Leiden University Medical Center (LUMC), bringing together 35 participants from our academic and co-financing partners, as well as members of the Advisory Board. The event kicked off with research updates from all work packages, providing a comprehensive overview of the progress made across various projects. The evening concluded with an engaging dinner, where most attendees gathered to continue discussions in a more informal setting. On the second day, we introduced a new breakout session format to explore...

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Theano Tsikari is invited to give talks and received a travel grant

Theano Tsikari, PhD student within LymphChip at the Orlova lab at LUMC, has been selected to give a flash talk and has also received a travel grant for the EMBO workshop entitled “Building networks: engineering in vascular biology” which is held in Barcelona on May 6-8, 2024. In addition, she has been invited to give a short talk at the Annual EUROoCS meeting that will take place on July 3-5 in Milan. On both occasions, Theano will present her results on the integration of hiPSC-derived macrophages in a 3D vessel-on-chip model.

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LymphChip Summer School 2024

Researchers of both LymphChip and SmartOoC academic partners are invited to attend the LymphChip Summer School 2024 which will feature workshops on career development, business development, academic writing and scientific illustrations. The deadline for registration is May 1, 2024. For more information, please contact Anne Leferink.

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Kick-off Immuno-Gut (spin-off LymphChip Helpathon)

The kick-off meeting of Immuno-Gut took place on March 28, 2024 at the Mirai House home of the Department of Anatomy and Embryology of LUMC. This project is financed with a phase 1 Create2Solve grant from ZonMw and aims at the optimization and standardization of methods to produce serum and Matrigel free iPSC derived immune competent intestine via an intra- and inter-laboratory validation study. Sue Gibbs from Amsterdam UMC, location VUMc coordinates this project in a collaboration with LUMC and NCardia. The foundation for this project was laid during the LymphChip Helpathon #8 on...

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Technology Seminar on custom-made specialty polymers

Hans van der Aa, COO of PolyVation, gave a technology seminar in which he presented the capabilities of PolyVation and the various applications of their custom-made polymers. Depending on the need of the customer, the properties of the polymers can be tweaked to control for instance the physical and biological properties of the materials. Application areas of these polymers include medical devices, tissue engineering and drug delivery.  Within LymphChip, the PolyVation polymers are used for the biofabrication of biomimetic 3D microscaffolds for advanced skin‑ and gut-on-chip models...

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Nikon Imaging Course

On March 19 and 20, 2024 five PhD students attended an Organ-on-Chip imaging course designed to deepen their understanding of intricate 3D imaging and analysis techniques. This course was organized by the Nikon BioImaging Lab in Leiden. In preparation for this two-day course an online technical seminar was held in which the imaging possibilities were presented. Subsequently, the students filled in a form to inform the instructors about their specific imaging questions and objectives which led to the practical course for which the students could bring their own samples. For more...

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